CRP and Sepsis: It is perhaps particularly noteworthy that the AUC values of NPC2 in predicting the occurrence of septic shock or sepsis mortality are at the similar level as common sepsis prognostic markers, such as procalcitonin and c-reactive protein, and dysfunction markers of kidney (i.e. plasma creatinine) and coagulation (i.e. platelet count), demonstrating the prognostic value of plasma NPC2 in sepsis.