Wnt5A exhibited dual function in tumors both tumor promoting and supressor16 by the different mechanism including the activity of its isoforms Wnt5A-long (Wnt5A-L) and Wnt5A-short (Wnt5A-S), binding to specific receptors, downstream effectors, exogenous inhibitors, and tumor microenvironments, as well as the extracellular matrix, particularly cell/tissue-tropic contexts17. This evidence concerns the gene WNT5A and neoplasm.