Interestingly, when looking at earlier markers in cell fate determination, such as the Notch inhibitory ligand DLK1, a known inhibitor of adipogenesis20,21, or WNT10B, a stimulator of osteoblasts22, we found significantly decreased expression of DLK1 in BMSC from MDS and AML samples, whereas expression levels of the Notch receptors NOTCH1 and NOTCH3 as well as WNT10B were not changed (Fig. 4B). This evidence concerns the gene NOTCH1 and acute myeloid leukemia.