BCL2 and colonic neoplasm: Gossypol analog Ch282-5 (2-aminoethanesulfonic acid sodium-gossypolone) exhibits anti-proliferative and pro-cell death activity against colon cancer cells both in vitro and in vivo, and the response of colon cancer cells to the drug correlates with Ch282-5′s inhibition of anti-apoptotic Bcl-2 proteins, induction of mitochondria-dependent apoptotic pathway, and disruption of mitophagy and mTOR pathway29.