We observed a dramatically higher expression of Shc3 in HCC tumor than in the para-tumors (82.69%, 43 of 52); higher MDR1 transcript levels were observed in 80.76% (42 of 52) of HCC samples than its corresponding para-tumor tissues (Fig. 1A, B and Table S1). This evidence concerns the gene SHC3 and hepatocellular carcinoma.