Higher expression of Shc3 was detected in 46 of the 72 samples when expression of Shc3 was compared with that of the corresponding non-tumor liver tissues (Table 1), and Shc3 protein expression was similar to P-gp protein expression in HCC samples (χ2 = 7.127, P = 0.007). Here, PGP is linked to hepatocellular carcinoma.