In phase II metastatic melanoma study, combinatorial treatment with DC vaccine (peptide-pulsed or whole-tumor lysate), IL-2 and metronomic Cy and Celecoxib (a COX2 inhibitor) was safe, and 16 out of 28 (57%) patients experienced stable diseases (NCT00197912; www.clinicaltrials.gov)30. This evidence concerns the gene IL2 and neoplasm.