MAP3K14 and glioblastoma: To explore whether NIK plays a role in regulating changes in mitochondrial morphology and metabolism in response to different bioenergetic demands, we used Seahorse XF analyzer MitoStress assays to evaluate mitochondrial function in GBM cells cultured under different nutrient conditions to induce a metabolic shift from glycolysis to forced reliance on OXPHOS21,25.