Interestingly, among these were two genes involved in stress signalling and depressive disorders, namely Fkbp5 (encoding FK506 binding protein 5 (FKBP5), a regulator of glucocorticoid receptor (GR) activity) and Adrb1 (encoding the beta-1 adrenergic receptor (β1-AR)). Here, ADRB1 is linked to depressive disorder.