CD8A and chronic pancreatitis: To interrogate the cellular basis in the inflammatory microenvironment by which MLN4924 promotes chronic pancreatitis, we examined the infiltration of total T cells, T-cell subsets (including CD4+ T cells, CD8+ T cells, Th17 cells and Treg cells) and NK cells, and found that there were no differences in frequencies of these cells between MLN4924-treated CP tissues and control CP tissues, which suggesting that neddylation might not affect the infiltration of these cells in CP (Fig. S1A–C).