Moreover, it has also been reported that retinal neuron loss is preceded by the mislocalization of TDP-43 in Grn-KO mice37 and that increased cytoplasmic TDP-43 induces retinal degeneration, including thinning of the retina, in a Drosophila ALS model38,39. The gene discussed is GRN; the disease is amyotrophic lateral sclerosis.