GPT and metabolic dysfunction-associated steatohepatitis: Overall, an enhanced remodelling of the lipidome toward desaturated lipids is expected to reduce lipotoxicity in murine models of NASH [28]; accordingly, the Insig1 KO mice showed reduced hepatocyte damage with ALT values below the upper limit of normal (Figure S2P) which, although “clinically” significant, did not reach statistical significance.