Overall, an enhanced remodelling of the lipidome toward desaturated lipids is expected to reduce lipotoxicity in murine models of NASH [28]; accordingly, the Insig1 KO mice showed reduced hepatocyte damage with ALT values below the upper limit of normal (Figure S2P) which, although “clinically” significant, did not reach statistical significance. Here, INSIG1 is linked to metabolic dysfunction-associated steatohepatitis.