In our cohort of biopsy-proven NASH patients, transcriptomic analysis suggested that the transcriptional complex of sterol regulatory element-binding protein 1 and 2 (SREBP1/SREBF1 and SREBP2/SREBF2) and SREBP cleavage-activating protein (SCAP) were strongly activated; this was associated with enhanced metabolic programmes governing cholesterol/lipid synthesis and remodelling. Here, SREBF2 is linked to metabolic dysfunction-associated steatohepatitis.