In line with our previous observations where we defined that Insig1 KO mice were smaller/shorter (but not leaner) than their WT littermates [15], Insig1 KO mice body weights (Figure S2A) were reduced compared to the other genotypes without genotype-associated differences in fat mass (Figure S2B), liver weight to body weight ratio (Figure S2C), metabolic biochemistry (Figsure S2D–G: glucose, TG, cholesterol, and free fatty acid), or markers of systemic and peripheral insulin resistance (Figures. Here, INSIG1 is linked to Insulin resistance.