GAD1 and schizophrenia: This is of special interest, as evidence from post-mortem and preclinical research suggest increased amygdala reactivity in schizophrenia may be due to either increased activity of a local feedforward excitation circuit (Benes, 2010) or decreased regulation from the prefrontal cortex (Aleman and Kahn, 2005), which could be concomitant to decreased GABA-synthesising enzyme GAD67 function in the hippocampus (Benes, 2010).