Through in vitro experiments, it was found that sophoridine can inhibit macrophage-mediated immunosuppression through the TLR4/IRF3 pathway and then up-regulate the killing effect of CD8+ T cells on gastric cancer, thus reshaping the immune microenvironment of gastric cancer, which provides a preclinical basis for the clinical application of sophoridine [114]. This evidence concerns the gene TLR4 and gastric cancer.