Cancer inflammation-related fibroblasts in bladder cancer produce VEGF, including VEGFA and VEGFB, which bind to VEGF receptors (FLT1, KDR, MET and FLT4) on endothelial cells, promote angiogenesis, affect the proliferation of cancer cells and stromal cells, and may recruit immune cells into the cancer stage [27]. The gene discussed is KDR; the disease is cancer.