For example, Guo et al. found that rapamycin (RapA) is a mTOR inhibitor that can provide significant efficacy in the treatment of melanoma in xenograft models through antiangiogenic activity and can be co-cultured with cisplatin because RAPA makes A375 melanoma cells sensitive to cisplatin through microenvironmental regulation [122]. The gene discussed is MTOR; the disease is melanoma.