IL6 and familial pancreatic carcinoma: Marsh et al. found that embelin can inhibit the growth of pancreatic cancer in KrasG12D mice by increasing the infiltration of Th1 cells, NK cells, CTLs, γδT cells and NKT cells, and reducing the infiltration of Th17, PMN-MDSC, and IL-8- and IL-6-positive immune cells, thus regulating the cancer-immune microenvironment [136].