As an example, Miao and colleagues [70] have proposed that mRNA formulations exploiting an unsaturated lipid tail, a dihydroimidazole linker and cyclic amine head groups confer profound activation of APCs via the intracellular stimulator of interferon genes (STING) pathway, rather than through TLRs, thereby reducing systemic cytokine expression and increasing anti-tumor efficacy. Here, STING1 is linked to neoplasm.