Through analysis of the microarray dataset GSE38241 in GEO database, we found that PKM2 was a significantly up-regulated gene (P = 0.0104) (Fig. 3c), while FURIN was not statistically different between normal tissues and PCa tissues (P = 0.111), indicating that PKM2 was a key downstream gene of miR-541-3p. Here, PKM is linked to posterior cortical atrophy.