KLK3 and posterior cortical atrophy: Inspiringly, due to the significance of personalized PCa screening has been increasingly prominent, traditional PSA screening strategies are urged to be developed [60] and considering the serum level of melatonin or the level of its metabolite is closely related to the risk of PCa, it deserves further exploring that whether the combined detection of PSA and melatonin can further improve the efficiency of existing PCa screening methods.