CircPAN3 (hsa_circ_0100181) could mediate the chemoresistance of AML cells through circPAN3 − miR-153-5p/miR-183-5p − XIAP axis [12], and circDLEU2 (hsa_circ_0000488) could promote AML cell proliferation and inhibited cell apoptosis through circDLEU2 − miR-496 − PRKACB axis [13]. The gene discussed is PRKACB; the disease is acute myeloid leukemia.