AKT1 and diabetes mellitus: Another study reported that the inhibition of PKCδ promoted metabolic activity and expansion of the hematopoietic stem and progenitor cells partially through the PI3K/Akt pathway.30 PKCδ-induced alteration of EC function in diabetes was corroborated by a similar Akt inhibition pattern observed in isolated EC from the lungs of diabetic ec-Prkcdf/f mice.