Indeed, PKCδ isoform is involved in several cardiovascular diseases10 and systemic deletion of PKCδ has been shown to accelerate arteriosclerotic lesions in mice35 and enhance the expression of connective tissue growth factor in cardiomyocytes leading to the progression of cardiac fibrosis in diabetic cardiomyopathy.36 This evidence concerns the gene CCN2 and diabetic cardiomyopathy.