In breast cancer, AQP4 had a low expression in comparison with non-tumor tissues, andthe patients with the lowest expression level had poor survival (Shi et al., 2011; Zhu et al., 2019).Additionally, down-regulation of AQP4 inhibits proliferation, migration, andinvasion in breast cancer cell lines (Li et al.,2016). This evidence concerns the gene AQP4 and neoplasm.