DES and proteostasis deficiencies: PA28α overexpression also prolongs life span of mice suffering from a heart‐specific desmin proteinopathy (Li, Horak, et al., 2011), delays disease progression in two photoreceptor degeneration mouse models (Lobanova et al., 2018), and PA28αβ has been shown to increase proteasomal degradation of oxidatively damaged hemoglobin (Pickering & Davies, 2012).