ChIP analysis of randomly selected genes (HOXA4, HOXA‐AS2, and HOXD13) confirmed the marked H3K27me3 loss associated with H3K4me3 and H3K9ac enrichment in seven IDHwt glioma samples from our cohort (Fig. 5B, Fig. S5B). Here, HOXD13 is linked to central nervous system cancer.