HOXA1 and central nervous system cancer: Accordingly, all members, but HOXD10, of the core HOX signature of IDHwt samples (i.e., upregulation of HOXA1, A5, A6, A7, A10, D9, and D10) have an oncogenic role in gliomas, by promoting cell viability and migration or by reducing cell death of GBM cell lines [18, 19, 33, 34].