(d) Significant correlations between the expression of genes in a candidate PES and three lung function PES (FVC): class B/2 secretin family receptors, circadian clock, and pathways in cancer. The relationship between PES and gene expression is presented as a volcano plot, where the x-axis is the t value (coefficient divided by standard error) and the y-axis is the –log10p-value, with higher points more significant. The gene discussed is CLOCK; the disease is cancer.