CLOCK and cancer: We identified a significant association between the FVC PES class B/2 [secretin family receptors] and the expression of WNT3 using a strict FDR threshold q < 0.05 (t = −3.53, p=4.71×10−4, q = 0.028); a more lenient FDR cut-off (q < 0.1) yielded two more significant PES–gene expression correlations: FVC circadian clock PES and PPARA: t = −3.23, p=1.37×10−3, q = 0.07; FVC pathways in cancer and HSP90AB1: t = 3.72, p=2.33×10−4, q = 0.066.