Notably, in the present study, substantial plaques are formed in Il4-/-Il13-/- mice (average plaque size of 319,293 μm2; Figure 1C), and our previously published data have shown atherosclerosis regression in significantly smaller plaques (<200,000 μm, Basu et al., 2018; Sharma et al., 2020). Here, IL4 is linked to atherosclerosis.