And the HR of the high-risk group is 4.56 (2.87–7.25) times danger than that of the low-risk group (Figure 1C) The result of the multivariable Cox regression analysis of 12 genes along with clinicopathologic features was revealed in Figure 1D, indicating that most of these genes except MC1R can also act as independent prognostic factors, and may have an excellent suggestive effect on predicting the survival of COAD patients. This evidence concerns the gene MC1R and colon adenocarcinoma.