GJC2 and Barrett esophagus: This gene and SLC22A18, PIGR, and GJA12 can effectively divide Barrett’s Esophagus into three groups with different risks and can detect dysplasia/early-stage neoplasia (Alvi et al., 2013).TPM1, as a tumor suppressor gene, was found to be significantly downregulated in colorectal cancer, mainly because of epigenetic and genetic events, which are closely related to the occurrence of colorectal cancer (Mlakar et al., 2009).