TF and chronic kidney disease: Previous studies in Japanese patients with CKD have shown that the Hb concentration, serum iron concentration, transferrin saturation and serum ferritin concentration were increased and that transferrin iron-binding capacity (TIBC) was decreased undergoing FC treatment (dose adjusted between 1.5 and 6.0 g/day), suggesting that these changes were due to the utilization of iron provided by FC [7–9].