In order to further investigate the effect of M2 macrophage-derived exosomal miR-155-5p on immune escape in colon cancer, we treated the exosomes derived from M2 macrophages with miR-155-5p inhibitor, and ZC3H12B was overexpressed in SW48 cells treated with exo-miR-155-5p inhibitor. This evidence concerns the gene ZC3H12B and malignant colon neoplasm.