Accordingly, SCLC can be classified today into NE-high and NE-low subtypes primarily based on the expression pattern of different NE markers such as chromogranin A (CHGA), synaptophysin (SYP), neural cell adhesion molecule 1 (NCAM1/CD56), and gastrin-releasing peptide (GRP).5 This evidence concerns the gene SYP and small cell lung carcinoma.