This process is part of the dysregulation of the immune system during sepsis and is characterized by high levels of circulating IL-6 and IL-10 and the decreased ability of monocytes, macrophages, and dendritic cells to produce hyperinflammatory cytokines, such as TNF-α and interferon gamma (IFN-γ) in response to PAMPs and DAMPs. Here, TNF is linked to Sepsis.