The role of transcriptomes such as sperm motility cation channel sperm associated 1 (CATSPER1) and sperm associated antigen 1 (SPAG1) in fertility and development of sperm hyperactivated motility has been clearly demonstrated in infertile male candidates; the knockout studies indicated that these transcripts are indispensable for the structural integrity of sperm (94, 95). The gene discussed is CATSPER1; the disease is Infertility.