≥30 years of age; clinical diagnosis of type 2 diabetes; glycated hemoglobin level of 6.5–12.0%; eGFR 30~90 ml·min−1·(1.73 m2)−1; urine albumin: creatinine ratio 300~5,000 mg·g−1. The gene discussed is ALB; the disease is type 2 diabetes mellitus.