NOS3 and type 2 diabetes mellitus: • (–) Risk of coronary heart disease, stroke, T2DM • (+) GIT microbiota • (–) Arterial thrombosis • (+) Flow-mediated dilation • (–) Systolic blood pressure • (+) EPCs • Lower vitamin B12 associated with arterial endothelial dysfunction • (+) Phosphorylation of eNOS by ECs