Taken together, this evidence provides persuasive and plausible roles of MeDiet, DASH, GFD, and vegetarian diets in the regulation MP systemic release in guarding against microthrombi formation, whereas the formation of MPs with procoagulant TF and proinflammatory properties following WPD, HFD, and LCD is recognized to heighten the risk for microthrombosis and arteriosclerosis and/or arteriolosclerosis (368, 369) and hence risk for CSVD manifestations. This evidence concerns the gene TF and arteriolosclerosis.