• (–) Risk of coronary heart disease, stroke, T2DM • (+) GIT microbiota • (–) Arterial thrombosis • (+) Flow-mediated dilation • (–) Systolic blood pressure • (+) EPCs • Lower vitamin B12 associated with arterial endothelial dysfunction • (+) Phosphorylation of eNOS by ECs. The gene discussed is NOS3; the disease is coronary artery disorder.