Furthermore, legume (highly soluble fiber) consumptions also reported to reduce the risk of developing vascular disease, i.e., improve cholesterol level, lower GI, blood pressure, CRP, E-selectin, IL-6, TNF-α, VCAM-1, ICAM-1, and waist circumference and prevented T2DM (299–301). The gene discussed is CRP; the disease is type 2 diabetes mellitus.