A total of 30 patients with advanced EGFR/ALK wild-type (WT) NSCLC who received PD-1/PD-L1 inhibitors were recruited by Peng et al., and plasma exosomal miRNAs were profiled using small RNA next-generation sequencing (Peng et al., 2020). The gene discussed is ALK; the disease is non-small cell lung carcinoma.