Among the 26 genes, SLC16A10, ESCO1, ESCO2, KAT1, HDAC1, HDAC2, HDAC3, HDAC7, HDAC8, SIRT6, SIRT7, and LEF1 were found to be risk factors in glioma, with hazard ratios >1, whereas KAT2A, KAT2B, KAT5, KAT6A, KAT6B, KAT7, CREBBP, EP300, HDAC11, HDAC4, HDAC5, SIRT1, SIRT3, and SIRT5 were protective factors, with hazard ratios <1. The gene discussed is HDAC2; the disease is central nervous system cancer.