HDAC1 and central nervous system cancer: Therefore, to exclude the potential influences of 1p/19q codeletion, we compared the mRNA expression levels of HDAC1 and SIRT2 according to CNV status, as well as the OS rates between low and high levels of HDAC1 and SIRT2 mRNA expression in gliomas without HDAC1 or SIRT2 CNVs (Figures 7B,C).