Among these LARs that showed increased expression with increasing WHO grade in both the CGGA and TCGA datasets, HDAC1 is the best-studied LAR in glioma, whereas the potential functions of ESCO2, KAT1, LEF1, and SLC16A10 are unreported in this cancer (Figures 1C,D). This evidence concerns the gene ESCO2 and central nervous system cancer.