Among these LARs that showed increased expression with increasing WHO grade in both the CGGA and TCGA datasets, HDAC1 is the best-studied LAR in glioma, whereas the potential functions of ESCO2, KAT1, LEF1, and SLC16A10 are unreported in this cancer (Figures 1C,D). The gene discussed is HAT1; the disease is central nervous system cancer.