The CNVs for the other four LARs–KAT6B (10q), SIRT1(10q), HDAC10 (22q), and HDAC9 (7q)–were highly associated with the risk signature and may be affected in chromosomal alterations such as 10q−, 22q− and 7+ in gliomas. Here, SIRT1 is linked to central nervous system cancer.