To gain a better understanding of the relationship between insulin resistance and plasma lipoprotein subclass profile in non-obese people, we recruited two groups of lean Asians, matched for age, sex and BMI, and evaluated insulin sensitivity by an intravenous glucose tolerance test (IVGTT) and lipoprotein subclasses by proton nuclear magnetic resonance (1H-NMR) spectroscopy. This evidence concerns the gene INS and Insulin resistance.