INS and prediabetes syndrome: However, our two study groups had very similar HOMA-IR values to those reported previously in insulin-sensitive and insulin-resistant individuals (0.9–1.6 and 1.7–2.5, respectively) (16–18), and also comparable IVGTT-derived Si values to those in overweight/obese subjects with normal glucose tolerance and prediabetes (3.8 and 1.6, respectively) (40).