When combined with celecoxib, a cyclooxygenase 2 (COX2) inhibitor, this low CHO, high protein diet not only reduced lung metastasis of 4T1 mammary tumors in Balb/C mice, but also lowered the incidence of metastasis in the male Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice (37). Here, PTGS2 is linked to breast cancer.