Transforming growth factor-beta (TGF-β) consists of 3 isoforms (TGF-β1, TGF-β2 TGF-β3), TGF-β1 is well-established as an indispensable driver of renal fibrosis in the pathogenesis of CKD, while the role of TGF-β2 and TGF-β3 remains largely undefined (11, 19–21). The gene discussed is TGFB3; the disease is renal fibrosis.