Physical activity (PA) acts favorably in NAFLD primarily by reducing intrahepatic fat content with β-oxidation of fatty acids and lipogenesis regulation, enhancing the expression and activity of PPAR-γ, insulin sensitivity, and hepatoprotective autophagy, reducing hepatocyte apoptosis, and inflammation of the liver by decreasing the proinflammatory mediators. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.