RNA interference (RNAi)-mediated suppression of PIWIL1 expression in tumor cells reduced proliferation, migration, invasion, EMT, sphere formation and angiogenesis (Zhao et al., 2012; Wang D.W. et al., 2014; Wang X. et al., 2014; Li et al., 2020; Shi et al., 2020). Here, PIWIL1 is linked to neoplasm.