Cases with digenic heterozygous mutations in GJB2 and GJB6 are relatively rare in the NSHL population, with various phenotypes, such as prelingual or post-lingual, ranging from mild or moderate to severe or profound hearing loss (Bolz et al., 2004; Cama et al., 2009; Chan et al., 2010; del Castillo and del Castillo, 2011; Mei et al., 2017). This evidence concerns the gene GJB6 and nodular sclerosis classical Hodgkin lymphoma.