Interestingly, these titin modifications in the infarcted hearts were mediated by the inflammatory cytokine interleukin-6 (IL-6) (Kötter et al., 2016), which is expressed in the early inflammatory phase 3–72 h post myocardial infarction (Frangogiannis, 2006). The gene discussed is TTN; the disease is myocardial infarction.