CTSS and neoplasm: In several cancer types, such as prostate cancer and melanoma, redistribution of lysosomes at the PM has been shown to cause the extracellular release of lysosomal proteases, namely cathepsins, likely via lysosomal exocytosis, which remodels the ECM and facilitates tumor growth and invasion (Rozhin et al., 1994; Nishimura et al., 1998; Steffan et al., 2009; Steffan et al., 2014).