Following this principle, inhibition of N-MYC in MYCN-amplified neuroblastoma cell lines induced a differentiation morphology as well as upregulation of neural differentiation genes (Kang et al., 2006; Henriksen et al., 2011; Jiang et al., 2011; Westermark et al., 2011; Hossain et al., 2013). This evidence concerns the gene MYCN and neuroblastoma.