SNAP29 and hereditary disease: Thus, our data showing that depletion of SNAP29 in NES cells produces GA fragmentation, spindle alterations, and impairment in mitotic progression with formation of micronuclei pave the way for generation of NES cells derived from induced pluripotent stem cells (iPSCs), which have been already used for mechanistic dissection of human genetic diseases of the CNS (Koch et al., 2011; Mertens et al., 2013).