CHRNA7 and synucleinopathy: In addition to regulating dopaminergic neuronal death and apoptosis via MAPK signaling (Xu et al., 2019) or Wnt/β-catenin signaling pathways (Liu et al., 2017), our results indicate that α7-nAChRs play an important role in α-synucleinopathy through enhancing the clearance of αSyn.