In the tumor-bearing animals, treatment with WFA led to a statistically significant dose-dependent transcriptional downregulation of Fbxo30, Fbxo32, Trim63, and Traf6 compared to the tumor-bearing vehicle-treated group (p < 0.0001 for all comparisons) (Figures 6C,D). The gene discussed is FBXO30; the disease is neoplasm.