HSPA5 and neoplasm: In the tumor-free mice, we observed: (1) transcriptional upregulation of Eif2ak3, Ddit3, Ppp1r15a, and Ern1, (2) downregulation of Hspa5 and Hsp90B1, and (3) no change in transcript levels of Atf4 and Tnfrsf10B in the WFA-treated groups compared to the vehicle-treated group (p < 0.001 or 0.0001 for most comparisons) (Figure 4).