Quite interestingly, the report from Pettersen et al. demonstrated that intra-tumoral Activin A signaling promotes the secretion of IL-6 from ovarian cancer cells, and that inhibiting this signaling axis can reduce the ability of cancer cells to accelerate autophagy and impede the induction of cachexia (Pettersen et al., 2020). The gene discussed is IL6; the disease is ovarian carcinoma.