TAM can be caused by heterozygous mutations in STIM1 or ORAI1 gene (Morin et al., 2020), both encoding for Ca2+ homeostasis key regulators, and CASQ1 gene (Barone et al., 2017; Böhm et al., 2018), encoding for calsequestrin, the major Ca2+ buffering protein in skeletal muscle SR. The gene discussed is ORAI1; the disease is transient myeloproliferative syndrome.