Inflammation instigated by NLRP3 has been shown to be fundamental to pathophysiological changes in diseases like cryopyrin-associated periodic fever syndrome (CAPS) (Agostini et al., 2004), myocardial infarction (Abbate et al., 2015), stroke (Ito et al., 2015), liver inflammation (Wree et al., 2014), type 2 diabetes (Masters et al., 2010), Alzheimer's disease (Heneka et al., 2013) Parkinson's disease (Gordon et al., 2018) and aging (Swanson et al., 2019; He et al., 2020; Weber et al., 2020). The gene discussed is NLRP3; the disease is Parkinson disease.