A growing number of pre-clinical in vivo models have since reported efficacy for MCC950, e.g., in models of cryopyrin-associated periodic syndrome [CAPS (Coll et al., 2015)], Alzheimer's disease [APP/PS1 model (Dempsey et al., 2017)], sarcoidosis [trehalose 6,6'-dimycolate-granuloma model (Huppertz et al., 2020)], atherosclerosis [ApoE model (Van Der Heijden et al., 2017)] or cystic fibrosis [Cftr transgenic model (Mcelvaney et al., 2019)]. Here, APP is linked to cryopyrin-associated periodic syndrome.