The piR-021285 variant mimics transfection into breast cancer cell lines and weakens pro-invasive and pro-apoptosis gene methylation of ARHGAP11A at the 5′-UTR-first exon CpG site, which results in higher ARHGAP11A expression and increased breast cancer cell invasiveness (Fu et al., 2015). Here, ARHGAP11A is linked to breast carcinoma.