RRS1 and cervical carcinoma: Gambe et al. (2009) detected high levels of RRS1 in the nuclear periphery of cervical cancer Hela cells, which bound to other nucleolar proteins during mitosis and interphase. The expression level of RRS1 was particularly increased at prophase during nucleolus breakage. RRS1 silencing significantly increased the number of tetraploid cells and significantly prolonged cell division, indicating a role in chromosome segregation (Gambe et al., 2009). Finally, down-regulation of RRS1 by miRN-148a inhibited the proliferation, invasion, and migration of cervical cancer cells (Zhang et al., 2019).