CAV1 and neoplasm: There CAV1 plays a controversial role; on the one hand, CAV1 reportedly limits the adaptation to stress in tumor cells through impairment of ER-mitochondria contacts (Bravo-Sagua et al., 2019); on the other hand, using livers from wild-type and CAV1-deficient mice, it was shown that CAV1 promotes ER-mitochondria contacts, thereby contributing to the recruitment and regulation of intracellular steroids and lipoprotein metabolism (Sala-Vila et al., 2016).